Perfection Is Skin Deep: Everyone Has Flawed Genes
When researchers looked at the genetic sequences of 179 individuals, they found far more defects in the patterns of As, Ts, Gs, and Cs than they expected. When researchers looked at the genetic sequences of 179 individuals, they found far more defects in the patterns of As, Ts, Gs, and Cs than they expected. We all know that nobody's perfect. But now scientists have documented that fact on a genetic level. Researchers discovered that normal, healthy people are walking around with a surprisingly large number of mutations in their genes. It's been well known that everyone has flaws in their DNA, though, for the most part, the defects are harmless. It's been less clear, however, just how many mistakes are lurking in someone's genes.
Keywords:
mutations people disease disease-causing mutations genetic mutations researchers genetic sequences defects known disease-causing mutations Wellcome Trust Sanger surprisingly large number entire genetic blueprints Tyler-Smith disease-associated mutations widespread genetic sequencing critical take-home medicine DNA genetic level healthy people Genomes project late-onset conditions Chris Tyler-Smith direct estimate long time indirect approaches United States big surprise American Journal Human Genetics heart disease large numbers interesting question weird thing similar gene disease gene average person Health News Genome Sequencing North Carolina new study James Evans genomic medicine good reason good news backup mechanisms Gs genes estimates scientists individualsPeople:
Chris Tyler-Smith
Overall Sentiment: 0.0258528
Relevance: 0.748465
| Sentiment | Quote |
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| 0.0348426 | "It's such an interesting question that people had been trying to make estimates from indirect approaches for a long time," says Chris Tyler-Smith ... |
| 0.0599954 | "It's such an interesting question that people had been trying to make estimates from indirect approaches for a long time," says Chris Tyler-Smith of the Wellcome Trust Sanger Institute in Cambridge, England. "There were estimates that ranged from just a handful up to 100 or more serious disease-associated mutations." |
| -0.376199 | "We found quite amazingly large numbers of deleterious and known disease-causing mutations," Tyler-Smith says. ... |
| 0 | "It could be that in some cases there's another copy of that gene or a similar gene that takes over," Tyler-Smith says. ... |
| 0.110335 | "It's a bit surprising that people should be walking around apparently healthy yet we're seeing known disease-causing mutations in their genomes," he says. ... |
| -0.104297 | "It's a bit surprising that people should be walking around apparently healthy yet we're seeing known disease-causing mutations in their genomes," he says. "But the answer was that these tended to be for mild and very often late-onset conditions. Things like heart disease, an increased risk of developing cancer." |
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James Evans
Overall Sentiment: 0.0740002
Relevance: 0.383892
Green
Overall Sentiment: -0.0977248
Relevance: 0.366056
| Sentiment | Quote |
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| 0.30115 | "The critical take-home medicine here — one that needs to be reinforced over and over — is that as we enter the age of genomic medicine, simply having a mutation in a disease gene does not mean you have the disease or will get the disease," Green says. ... |
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Additional Info:
HealthCondition: heart disease
Overall Sentiment: -0.271977
Relevance: 0.90031
Disambiguation: DiseaseOrMedicalCondition | CauseOfDeath | RiskFactor | Disease | OrganizationSectorReferences:
FieldTerminology: DNA
Overall Sentiment: -0.0218382
Relevance: 0.527689
FieldTerminology: Genome Sequencing
Overall Sentiment: -0.114998
Relevance: 0.334154
Organization: Wellcome Trust Sanger Institute
Overall Sentiment: 0
Relevance: 0.33785
Organization: University of North Carolina
Overall Sentiment: 0.144133
Relevance: 0.316011
Disambiguation: SportsTeam | FootballTeam | CollegeUniversity | UniversityReferences:
PrintMedia: American Journal of Human Genetics
Overall Sentiment: 0
Relevance: 0.368269
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Source : npr.org
Researchers found a surprising number of mutations, including several associated with disease, in the genes of normal healthy people. Their study raises questions about whether widespread genetic sequencing could end up scaring people for no good reason.
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Perfection Is Skin Deep: Everyone Has Flawed Genes
Source : npr.org
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